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Case Report
Understanding the behavior of a low-grade serous carcinoma
1 Fellow Gynecology-Oncologist, Department of Obstetrics & Gynecology, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
2 Trainee Lecturer, Department Obstetrics & Gynecology, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
3 Senior Lecturer/Consultant Gynecology-Oncologist, Department of Obstetrics & Gynecology, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
4 Clinical Lecturer, Department of Obstetrics & Gynaecology, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Address correspondence to:
Lee Saw Joo
Hospital Universiti Sains Malaysia, Jln. Raja Perempuan Zainab 2, 16150 Kubang Kerian, Kelantan,
Malaysia
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Article ID: 100023G06LJ2019
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How to cite this article
Joo LS, Ismail EHE, Ismail MP, Mahmood NMZN, Adnan WFW, Sung HP. Understanding the behavior of a low-grade serous carcinoma. Edorium J Gynecol Obstet 2019;5:100023G06LJ2019.ABSTRACT
Low-grade serous carcinoma (LGSC) of ovary represents 10% of all serous carcinoma of ovary and up to 7% of total ovarian malignancy. Lowgrade serous carcinoma being less common, hence have not been well studied. Here, we report a case of LGSC in a 22-year-old young woman in which her clinical presentation and her intraoperative findings were not in-line with her final histopathological diagnosis. Management of this patient has been challenging not only because of her young age, but also because LGSCs were found to be relatively chemoresistant as compared to its high-grade counterpart, however to date, there are no other more effective therapies with robust evidence. Nevertheless, reports on treatment with primary cytoreductive surgery followed by adjuvant hormonal therapy has shown promising results.
Keywords: Epithelial ovarian cancer, LGSC treatment option, Ovarian low-grade serous carcinoma, Type 1 and Type 2 epithelial ovarian carcinoma
SUPPORTING INFORMATION
Acknowledgments
The authors would like to thank Dr. Norzaliana Zawawi and Dr. Noorul Balqis Che Ibrahim of Pathology Department, HUSM for the histological images.
Author ContributionsLee Saw Joo - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Engku Husna Engku Ismail - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohd Pazudin Ismail - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Nik Mohd Zaki Nik Mahmoo - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Wan Fadhlina Wan Adnan - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hoo Pek Sung - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Source of SupportNone
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Lee Saw Joo et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
