Edorium Journal of

Gynecology and Obstetrics

 
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Original Article
 
Maternal serum adiponectin, leptin and adiponectin-leptin ratio as possible biomarkers of preeclampsia
Linda Ahenkorah Fondjo1, Enoch Appiah Adu Gyamfi2, William K. B. A. Owiredu1, Cornelius Archer Turpin3, Daniel Asante Mante4, Enoch Odame Anto2
1Lecturer, Molecular Medicine, KNUST, Kumasi, Ghana.
2Graduate Student, Molecular Medicine, KNUST, Kumasi, Ghana.
3Professor, Obstetric and Gyneacology, KNUST/SMS, Kumasi, Ghana.
4Medical Director, Obstetric and Gyneacology, Manhyia Government Hospital, Kumasi, Ghana.

Article ID: 100013G06LF2016
doi:10.5348/G06-2016-13-OA-7

Address correspondence to:
Linda Ahenkorah Fondjo
Department of Molecular Medicine
Kumasi
Ghana, +233

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How to cite this article
Fondjo LA, Gyamfi EAA, Owiredu WKBA, Turpin CA, Mante DA, Anto EO. Maternal serum adiponectin, leptin and adiponectin-leptin ratio as possible biomarkers of preeclampsia. Edorium J Gynecol Obstet 2016;2:41–47.


Abstract
Aims: Preeclampsia is associated with significant maternal and perinatal morbidity and mortality, yet biomarkers for the condition have not been fully elucidated. As such, diagnosis of the condition in Ghana is based on blood pressure and urine protein measurement. The aim of this study was to compare the levels of adiponectin, leptin and the adiponectin-leptin ratio between normotensive pregnancy and preeclampsia.
Materials and Methods: 60 normotensive pregnant women and 60 preeclamptic women were recruited for this case-control study. Social and clinical information were obtained from all the participants. Maternal serum adiponectin and leptin were quantified using immunoassays. Differences in measured variables between groups were assessed with unpaired student's t-test; and associations among variables were described with Pearson's correlation coefficients.
Results: Adiponectin levels (p=0.001), leptin levels (p=0.010) and the adiponectin-leptin ratio (p=0.001) were higher in preeclampsia than in normotensive pregnancy. There was a significant inverse correlation between adiponectin and leptin in the normotensive controls (r=-0.768, p=0.002) but this relationship was attenuated in preeclampsia (r=-0.290, p=0.052).
Conclusion: Levels of adiponectin, leptin and the adiponectin-leptin ratio were elevated in the preeclamptic women and could serve as biomarkers for the diagnosis of preeclampsia.

Keywords: Adiponectin, Adiponectin-leptin ratio, Biomarkers, Body mass index, Leptin, Preeclampsia


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Author Contributions:
Linda Ahenkorah Fondjo – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Enoch Appiah Adu Gyamfi – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
William K.B.A. Owiredu – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Cornelius Archer Turpin – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Daniel Asante Mante – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Enoch Odame Anto – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Linda Ahenkorah Fondjo et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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